The community of the Fourth Creek Congregation consisted of Scots-Irish Presbyterians who first arrived in the Province of North Carolina in the mid to late 1730s and established a congregation by 1750 under Pastor John Thompson in Anson County. This area later became Rowan County in 1753 and, eventually, Iredell County in 1788. The site of the Fourth Creek Congregation was chosen as the location of the county seat of Iredell County in 1789 and was named Statesville that same year. The Fourth Creek Presbyterian Church was officially renamed the First Presbyterian Church of Statesville in 1875.